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Treatment of mice with 2APB 2APB (Sigma, D9754) was made fresh for each experiment (dissolved in DMSO at 100 mg/ml as the stock)

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Despite several advances, unresolved issues include the impact of protumorigenic and antitumorigenic mechanisms in different cell types and the mechanisms by which the antioxidant transcription factor network functions at various stages of tumorigenesis

Circ Res 81:297303 Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS (2005) Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes